Thursday, Apr. 10, 2008; 4:26 AM

WASHINGTON (Reuters) – Middle-aged men who ate seven or more eggs a week had a higher risk of earlier death, U.S. researchers reported on Wednesday.

Men with diabetes who ate any eggs at all raised their risk of death during a 20-year period studied, according to the study published in the American Journal of Clinical Nutrition.

The study adds to an ever-growing body of evidence, much of it contradictory, about how safe eggs are to eat. It did not examine what about the eggs might affect the risk of death.

Men without diabetes could eat up to six eggs a week with no extra risk of death, Dr. Luc Djousse and Dr. J. Michael Gaziano of Brigham and Women’s Hospital and Harvard Medical School found.

“Whereas egg consumption of up to six eggs a week was not associated with the risk of all-cause mortality, consumption of (seven or more) eggs a week was associated with a 23 percent greater risk of death,” they wrote.

“However, among male physicians with diabetes, any egg consumption is associated with a greater risk of all-cause mortality, and there was suggestive evidence for a greater risk of MI (heart attack) and stroke.”

They urged more study in the general population.

Eggs are rich in cholesterol, which in high amounts can clog arteries and raise the risk of heart attack and stroke.

One expert on nutrition and heart disease said the study suggests middle-aged men, at least, should watch how many eggs they eat.

“More egg on our faces? It’s really hard to say at this point, but it still seems, if you’re a middle-aged male physician and enjoy eggs more than once a day, that having some of the egg left on your face may be better than having it go down your gullet,” said Dr. Robert Eckel of the University of Colorado and a former president of the American Heart Association.

“But, remember: eggs are like all other foods — they are neither ‘good’ nor ‘bad,’ and they can be part of an overall heart-healthy diet,” Eckel wrote in a commentary.

The Harvard team studied 21,327 men taking part in the much larger Physicians’ Health Study, which has been watching doctors since 1981 who have agreed to report regularly on their health and lifestyle habits.

Over 20 years, 1,550 of the men had heart attacks, 1,342 had strokes, and more than 5,000 died.

“Egg consumption was not associated with (heart attack) or stroke,” the researchers wrote.

But the men who ate seven eggs a week or more were 23 percent more likely to have died during the 20-year period.

Diabetic men who ate any eggs at all were twice as likely to die in the 20 years.

Men who ate the most eggs also were older, fatter, ate more vegetables but less breakfast cereal, and were more likely to drink alcohol, smoke and less likely to exercise — all factors that can affect the risk of heart attack and death.

NEW YORK (Reuters Health) – Impaired insulin response appears to be involved in the development of Alzheimer’s disease, according to findings from a long-term population-based study conducted in Sweden.

Dr. Elena Uronema and colleagues at Upscale University analyzed data for 2,269 men who underwent glucose (blood sugar) tolerance testing at 50 years of age. After a follow-up at an average of 32 years, 394 men developed dementia or mental impairments, including 102 with confirmed Alzheimer’s disease and 57 with confirmed vascular dementia.

A low insulin response to intravenous glucose at the beginning of the study was associated with a 30 percent higher risk of Alzheimer’s disease.

Ronne AA’s group notes that an impaired insulin response is a predictor of Alzheimer’s disease. The risk, however, was not statistically significant only from subjects negative for the high-risk APOE-4 gene.

In contrast, impaired glucose tolerance was associated with vascular dementia, but not Alzheimer’s disease.

Overall dementia and cognitive risk was associated with high fasting serum insulin, insulin resistance, impaired insulin secretion, and glucose intolerance in subjects without dementia.

The study findings stress the importance of short- term and insulin, both were associated with short- and long-term exposure in the normal brain,” researchers conclude.

SOURCE: Neurology, April 9, 2008. (Online)

NEW YORK (Reuters) – Clinical trials of the inhaled insulin Exubera found increased cases of lung cancer, Pfizer Inc and Nektar Therapeutics said on Wednesday.

Over the course of the clinical trials, Pfizer said 6 of the 4,740 Exubera-treated patients versus 1 of the 4,292 patients not treated with Exubera developed lung cancer. One lung cancer case was also found after Exubera reached the market.

Pfizer updated the Exubera labeling to include a warning with safety information about lung cancer cases found in patients who used Exubera, which U.S. regulators approved in January 2006.

The warning states all patients who developed lung cancer had a history of cigarette smoking and that there were too few cases to determine whether the development of lung cancer is related to Exubera use.

Pfizer said it will stop marketing Exubera in October. Sales of the drug have been negligible.

The warning in the label stemmed from an ongoing review of data from the Exubera clinical trial program and post-marketing experience by Pfizer and the U.S. Food and Drug Administration, Pfizer said.