Archive for the ‘Conditions & Treatments’ Category

Checking Your Blood Glucose

Thursday, October 25th, 2007

People with diabetes work to keep their blood sugar (glucose) as near to normal as possible. Keeping your blood glucose in your target range can help prevent or delay the start of diabetes complications such as nerve, eye, kidney, and blood vessel damage.

When you learned you had diabetes, you and your health care team worked out a diabetes care plan. The plan aims to balance the foods you eat with your exercise and, possibly, diabetes pills or insulin. You can do two types of checks to help keep track of how your plan is working. These are blood glucose checks and urine ketone checks.

Blood Glucose Monitoring Checks

Blood glucose monitoring is the main tool you have to check your diabetes control. This check tells you your blood glucose level at any one time. Keeping a log of your results is vital. When you bring this record to your health care provider, you have a good picture of your body’s response to your diabetes care plan. Blood glucose checks let you see what works and what doesn’t. This allows you and your doctor, dietitian, or nurse educator to make needed changes.

Here is a table that lists blood glucose ranges for adults with diabetes:

Glycemic control

Who Should Check?

Experts feel that anyone with diabetes can benefit from checking their blood glucose. The American Diabetes Association recommends blood glucose checks if you have diabetes and are:

  • taking insulin or diabetes pills
  • on intensive insulin therapy
  • pregnant
  • having a hard time controlling your blood glucose levels
  • having severe low blood glucose levels or ketones from high blood glucose levels
  • having low blood glucose levels without the usual warning signs

Urine Checks

Urine checks for glucose are not as accurate as blood glucose checks. Urine testing for glucose should not be done unless blood testing is impossible.

A urine check for ketones is another matter. This check is important when your diabetes is out of control or when you are sick. You can find moderate or large amounts of ketones in urine when your body is burning fat instead of glucose for fuel. This happens when there is too little insulin at work. Everyone with diabetes needs to know how to check their urine for ketones.

How Blood Checks Work

You stick your finger with a special needle, called a lancet, to get a drop of blood. With some meters, you can also use your forearm, thigh or fleshy part of your hand. There are spring-loaded lancing devices that make sticking yourself less painful. Before using the lancing device, wash your hands or site you chose with soap and water. If you use your fingertip, stick the side of your fingertip by your fingernail to avoid having sore spots on the frequently used part of your finger.

Checking With a Blood Glucose Meter

Blood glucose meters are small computerized machines that “read” your blood glucose. In all types of meters, your blood glucose level shows up as a number on a screen (like that on your pocket calculator). Be sure your doctor or nurse educator shows you the correct way to use your meter. With all the advances in blood glucose meters, use of a meter is better than visual checking.

How to Pick a Meter

There are many meters to choose from. Some meters are made for those with poor eyesight. Others come with memory so you can store your results in the meter itself. The American Diabetes Association does not endorse any products or recommend one meter over another. If you plan to buy a meter, here are some questions to think about:

  • What meter does your doctor or diabetes educator suggest? They may have meters that they use often and know best.
  • What will it cost? Some insurance companies will only pay for a certain meter. Call your insurance company before you purchase a meter and ask how to get a meter and supplies. If your insurance company does not pay for blood glucose checking supplies, rebates are often available toward the purchase of your meter. You still have to consider the cost of the matching strips and lancets. Shop around.
  • How easy is the meter to use? Methods vary. Some have fewer steps than others.
  • How simple is the meter to maintain? Is it easy to clean? How is the meter calibrated (set correctly for the batch of strips you are using)?

Are meters accurate?

Experts testing meters in the lab setting found them accurate and precise. That’s the good news. The bad: meter mistakes most often come from the person doing the blood checks. For good results you need to do each step correctly. Here are other things that can cause your meter to give a poor reading:

  • a dirty meter
  • a meter or strip that’s not at room temperature
  • an outdated test strip
  • a meter not calibrated (set up for) the current box of test strips
  • a blood drop that is too small

Ask your health care team to check your skills at least once a year. Error can creep in over time.

Logging Your Results

When you finish the blood glucose check, write down your results and use them to see how food, activity and stress affect your blood glucose. Take a close look at your blood glucose record to see if your level is too high or too low several days in a row at about the same time. If the same thing keeps happening, it might be time to change your plan. Work with your doctor or diabetes educator to learn what your results mean for you. This takes time. Ask your doctor or nurse if you should report results out of a certain range at once by phone.

Keep in mind that blood glucose results often trigger strong feelings. Blood glucose numbers can leave you upset, confused, frustrated, angry, or down. It’s easy to use the numbers to judge yourself. Remind yourself that your blood glucose level is a way to track how well your diabetes care plan is working. It is not a judgment of you as a person. The results may show you need a change in your diabetes plan.

Checking for Ketones

You may need to check your urine for ketones once in a while. Ketones in the urine is a sign that your body is using fat for energy instead of using glucose because not enough insulin is available to use glucose for energy. Ketones in the urine is more common in type 1 diabetes.

Urine tests are simple, but to get good results, you have to follow directions carefully. Check to be sure that the strip is not outdated. Read the insert that comes with your strips. Go over the correct way to check with your doctor or nurse.

Here’s how most urine tests go:

  • Get a sample of your urine in a clean container.
  • Place the strip in the sample (you can also pass the strip through the urine stream).
  • Gently shake excess urine off the strip.
  • Wait for the strip pad to change color. The directions will tell you how long to wait.
  • Compare the strip pad to the color chart on the strip bottle. This gives you a range of the amount of ketones in your urine.
  • Record your results.

What do your results mean? Small or trace amounts of ketones may mean that ketone buildup is starting. You should test again in a few hours. Moderate or large amounts are a danger sign. They upset the chemical balance of your blood and can poison the body. Never exercise when your urine checks show moderate or large amounts of ketones and your blood glucoser is high. These are signs that your diabetes is out of control. Talk to your doctor at once if your urine results show moderate or large amounts of ketones.

Keeping track of your results and related events is important. Your log gives you the data you and your doctor and diabetes educator need to adjust your diabetes care plan.

When to Test

Ask your doctor or nurse when to check for ketones. You may be advised to check for ketones when:

  • your blood glucose is more than 300 mg/dl
  • you feel nauseated, are vomiting, or have abdominal pain
  • you are sick (for example, with a cold or flu)
  • you feel tired all the time
  • you are thirsty or have a very dry mouth
  • your skin is flushed
  • you have a hard time breathing your breath smells “fruity”
  • you feel confused or “in a fog”

These can be signs of high ketone levels that need your doctor’s help.

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Islet transplantation

Tuesday, October 23rd, 2007

If scientists can develop safe immunosuppressants that always work, then many people with type 1 diabetes may choose to have pancreas transplants. Until then, many doctors think islet transplants are a better option. Islets are clusters of cells in the pancreas that make insulin. In people with type 1 diabetes, islet cells are destroyed. Only 1-2% of the pancreas is made up of islet cells.

In pancreatic islet transplantation, cells are taken from a donor pancreas and transferred into another person. Once implanted, the new islets begin to make and release insulin. Researchers hope that islet transplantation will help people with type 1 diabetes live without daily injections of insulin.

The Edmonton Protocol

In the 1970s, islet transplant experiments were conducted with great success in laboratory mice. The excitement that those experiments generated soon turned to frustration, as initial attempts to reproduce that success in humans were largely disappointing. For many years progress was slow, and few transplant recipients were able to stay diabetes-free for more than a few months before the transplanted islet cells failed. But in recent years, scientists have begun to make rapid advances in transplant technology, and some of the most exciting new research comes to us from researchers at the University of Alberta in Edmonton, Canada. These scientists have used a new procedure called the Edmonton Protocol to treat patients with type 1 diabetes.

In this procedure, researchers use specialized enzymes to remove islets from the pancreas of a deceased donor. For an average-size person (70 kg), a typical transplant requires about 1 million islets, equal to two donor organs. Because the islets are extremely fragile, transplantation occurs immediately after they are removed.

The transplant itself is easy and takes less than an hour to complete. The surgeon uses ultrasound to guide placement of a small plastic tube (catheter) through the upper abdomen and into the liver. The islets are then injected through the catheter into the liver. The patient will receive a local anesthetic. If a patient cannot tolerate local anesthesia, the surgeon may use general anesthesia and do the transplant through a small incision.

It takes some time for the cells to attach to new blood vessels and begin releasing insulin. The doctor will order many tests to check blood glucose levels after the transplant, and insulin may be needed until control is achieved.

Benefits and Risks

Immunosuppressive or anti-rejection drugs are needed to keep the transplanted islets functioning. Researchers do not fully know what long-term effects these drugs may have. Also, although the early results of the Edmonton Protocol are very encouraging, more research is needed to answer questions about how long the islets will survive and how often the transplantation procedure will be successful.

However, transplanting islet cells has several advantages over transplanting a pancreas. First, unlike the pancreas transplant, an islet transplant is a minor surgical procedure, is less expensive, and is probably safer. Second, scientists may learn how to protect these cells from attack by the immune system. Several methods are already under study. If successful, the person with an islet transplant would not need to take immunosuppressants. Surgery would then be safer and more effective for many people with type 1 diabetes.

There is also continuing research on the transplantation of animal islets. Because the supply of human islets is severely limited, even the most successful method of human islet transplantation could only cure a small fraction of the people with diabetes through existing sources of human islets from donor pancreases. If islets from animal sources (for example, pigs) could be made to work successfully, a cure would be available for everyone. But transplants between species involve a whole new set of problems when it comes to regulating the body’s immune response, so much work will still have to be done to make that a possibility.

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Type 1 Diabetes Conditions & Treatments

Monday, October 22nd, 2007

In type 1 diabetes, the body does not produce insulin, which is needed to take sugar (glucose) from the blood to the cells. You can learn more about these conditions and how to prevent them in this section. You will also find helpful information about insulin, diagnostic tests and tips on what to expect from your health care provider.

Hypoglycemia
Hypoglycemia, or low blood glucose, can happen even during those times when you’re doing all you can to manage your diabetes.

Hyperglycemia
Hyperglycemia is a major cause of many of the complications that happen to people who have diabetes. For this reason, it’s important to know what hyperglycemia is, what its symptoms are, and how to treat it.

Ketoacidosis
Ketoacidosis is a serious condition where the body has dangerously high levels of ketones — or acids that build up in the blood — and it can lead to diabetic coma (passing out for a long time) or even death.

Managing Your Blood Glucose

Keeping your blood sugar (glucose) as close to normal as possible helps you feel better and reduces the risk of long-term complications of diabetes.

- Checking Your Blood Glucose
People with diabetes work to keep their blood glucose as near to normal as possible. Keeping your blood glucose in your target range can help prevent or delay the start of diabetes complications such as nerve, eye, kidney, and blood vessel damage.

- Tight Diabetes Control
Keeping your blood glucose levels as close to normal as possible can be a lifesaver. Tight control means getting as close to a normal (nondiabetic) blood glucose level as you safely can.

- A1C Test
An A1C test gives you a picture of your average blood glucose control for the past 2 to 3 months. The results give you a good idea of how well your diabetes treatment plan is working.

About Insulin and other drugs
In people with type 1 diabetes, the pancreas no longer makes insulin. The beta cells have been destroyed. They need insulin shots to use glucose from meals. Learn more about insulin and other drugs.

Insulin Therapy

Insulin Storage

Insulin Pumps
Learn how you can use an insulin pump to help manage your diabetes.

Transplantation
Diabetes sometimes damages kidneys so badly that they no longer work. When kidneys fail, one option is a kidney transplant. There are also pancreas transplants, as well as islet cell transplants.

- Kidney transplantation

- Pancreas transplantation

- Islet transplantation

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A1C Test

Monday, October 22nd, 2007

Because you have diabetes, you and your doctor, diabetes educator, and other members of your health care team work to keep your blood glucose (sugar) at ideal levels. There are two powerful reasons to work for effective blood sugar control:

  • You will feel better.
  • You may prevent or delay the start of diabetes complications such as nerve, eye, kidney, and blood vessel damage.

One way to keep track of your blood sugar changes is by checking your blood sugar at home. These tests tell you what your blood sugar level is at any one time.

But suppose you want to know how you’ve done overall. There’s a test that can help. An A1C (also known as glycated hemoglobin or HbA1c) test gives you a picture of your average blood glucose control for the past 2 to 3 months. The results give you a good idea of how well your diabetes treatment plan is working.

In some ways, the A1C test is like a baseball player’s season batting average. Both A1C and the batting average tell you about a person’s overall success. Neither a single day’s blood test results nor a single game’s batting record gives the same big picture.

How It Works

You know from the name that the test measures something called A1C. You may wonder what it has to do with your blood sugar control. Hemoglobin is found inside red blood cells. Its job is to carry oxygen from the lungs to all the cells of the body. Hemoglobin, like all proteins, links up with sugars such as glucose.

You know that when you have uncontrolled diabetes you have too much sugar in your bloodstream. This extra glucose enters your red blood cells and links up (or glycates) with molecules of hemoglobin. The more excess glucose in your blood, the more hemoglobin gets glycated. It is possible to measure the percentage of A1C in the blood. The result is an overview of your average blood glucose control for the past few months.

Thanks for the Memories

How does the A1C test look backward? Suppose your blood sugar was high last week. What happened? More glucose hooked up (glycated) with your hemoglobin. This week, your blood glucose is back under control. Still, your red blood cells carry the ‘memory’ of last week’s high blood glucose in the form of more A1C.

This record changes as old red blood cells in your body die and new red blood cells (with fresh hemoglobin) replace them. The amount of A1C in your blood reflects blood sugar control for the past 120 days, or the lifespan of a red blood cell.

In a person who does not have diabetes, about 5% of all hemoglobin is glycated. For someone with diabetes and high blood glucose levels, the A1C level is higher than normal. How high the A1C level rises depends on what the average blood glucose level was during the past weeks and months. Levels can range from normal to as high as 25% if diabetes is badly out of control for a long time.

You should have had your A1C level measured when your diabetes was diagnosed or when treatment for diabetes was started. To watch your overall glucose control, your doctor should measure your A1C level at least twice a year. This is the minimum. There are times when you need to have your A1C level tested about every 3 months. If you change diabetes treatment, such as start a new medicine, or if you are not meeting your blood glucose goals, you and your doctor will want to keep a closer eye on your control.

How Does It Help Diabetes Control?

How can your A1C test results help your control? Here are two examples.

Bob D., 49 years old, has type 2 diabetes. For the past seven years, he and his doctor have worked to control his blood sugar levels with diet and diabetes pills. Recently, Bob’s control has been getting worse. His doctor said that Bob might have to start insulin shots. But first, they agreed that Bob would try an exercise program to improve control.

That was three months ago. Bob stuck to his exercise plan. Last week, when the doctor checked Bob’s blood sugar, it was near the normal range. But the doctor knew a single blood test only showed Bob’s control at that time. It didn’t say much about Bob’s overall blood sugar control.

The doctor sent a sample of Bob’s blood to the lab for an A1C test. The test results would tell how well Bob’s blood sugar had been controlled, on average, for the past few months. The A1C test showed that Bob’s control had improved. With the A1C results, Bob and the doctor had proof that the exercise program was working. The test results also helped Bob know that he could make a difference in his blood sugar control.

The A1C test can also help someone with type 1 diabetes. Nine-year-old Lisa J. and her parents were proud that she could do her own insulin shots and urine tests. Her doctor advised her to begin a routine of two shots a day and to check her blood sugar as well.

Lisa kept records of all her test results. Most were close to the ideal range. But at her next checkup, the doctor checked her blood and found her blood sugar level was high. The doctor sent a sample of Lisa’s blood for an A1C test. The results showed that Lisa’s blood glucose control had in fact been poor for the last few months.

Lisa’s doctor asked Lisa to do a blood sugar check. To the doctor’s surprise, Lisa turned on the timer of her meter before pricking her finger and putting the blood drop on the test strip. The doctor explained to Lisa and her parents that the way Lisa was testing was probably causing the blood sugar test errors.

With time and more accurate blood sugar results, Lisa and her parents got better at using her results to keep food, insulin, and exercise in balance. At later checkups, her blood sugar records and the A1C test results showed good news about her control.

A1C tests can help:

  • Confirm self-testing results or blood test results by the doctor
  • Judge whether a treatment plan is working
  • Show you how healthy choices can make a difference in diabetes control.

Test Limit

Although the A1C test is an important tool, it can’t replace daily self-testing of blood glucose. A1C tests don’t measure your day-to-day control. You can’t adjust your insulin on the basis of your A1C tests. That’s why your blood sugar checks and your log results are so important to staying in effective control.

It is important to know that different labs measure A1C levels in different ways. If you sent one sample of your blood to four different labs, you might get back four different test results.

For example, an 8 at one lab might mean that blood glucose levels have been in the near-normal range. At a second lab, a 9 might be a sign that, on average, blood glucose was high. This doesn’t mean that any of the results are wrong. It does mean that what your results say depends on the way the lab does the test.

Talk to your doctor about your A1C test results. Know that if you change doctors or your doctor changes labs, your test numbers may need to be “read” differently.

The A1C test alone is not enough to measure good blood sugar control. But it is good resource to use along with your daily blood sugar checks, to work for the best possible control.

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What is Hyperosmolar Hyperglycemic Nonketotic Syndrome (HHNS)?

Sunday, October 21st, 2007

Hyperosmolar Hyperglycemic Nonketotic Syndrome, or HHNS, is a serious condition most frequently seen in older persons. HHNS can happen to people with either type 1 or type 2 diabetes, but it occurs more often in people with type 2. HHNS is usually brought on by something else, such as an illness or infection.

In HHNS, blood sugar levels rise, and your body tries to get rid of the excess sugar by passing it into your urine. You make lots of urine at first, and you have to go to the bathroom more often. Later you may not have to go to the bathroom as often, and your urine becomes very dark. Also, you may be very thirsty. Even if you are not thirsty, you need to drink liquids. If you don’t drink enough liquids at this point, you can get dehydrated.

If HHNS continues, the severe dehydration will lead to seizures, coma and eventually death. HHNS may take days or even weeks to develop. Know the warning signs of HHNS.

Warning Signs of HHNS

  • Blood sugar level over 600 mg/dl
  • Dry, parched mouth
  • Extreme thirst (although this may gradually disappear)
  • Warm, dry skin that does not sweat
  • High fever (over 101 degrees Fahrenheit, for example)
  • Sleepiness or confusion
  • Loss of vision
  • Hallucinations (seeing or hearing things that are not there)
  • Weakness on one side of the body
  • If you have any of these symptoms, call someone on your health care team.

How to avoid HHNS

The best way to avoid HHNS is to check your blood sugar regularly. Many people check their blood sugar several times a day, such as before or after meals. Talk with your health care team about when to check and what the numbers mean. You should also talk with your health care team about your target blood sugar range and when to call if your blood sugars are too high, or too low and not in your target range. When you are sick, you will check your blood sugar more often, and drink a glass of liquid (alcohol-free and caffeine-free) every hour. Work with your team to develop your own sick day plan.

Related information

Another condition to watch signs for is ketoacidosis, which means dangerously high levels of ketones, or acids, that build up in the blood. Ketones appear in the urine when your body doesn’t have enough insulin, and can poison the body.

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