Archive for the ‘Eye Complications’ Category

Drug Fights Diabetic Eye Disease

Saturday, October 4th, 2008

THURSDAY, Sept. 25 (HealthDay News) — New studies published this week in the The Lancet provide further evidence that candesartan, a blood pressure medicine, can cut the risk and severity of retinopathy in people who have diabetes.

“We suggest that clinicians may wish to consider using candesartan [brand name Atacand] in people with type 1 diabetes with hard-to-control blood glucose, who do not currently have retinopathy,” said one study’s British co-author, Dr. Nish Chaturvedi, of the National Heart and Lung Institute and Imperial College at St Mary’s, London. “In type 2 diabetes, in people with established retinopathy who become hypertensive, again the clinician may wish to consider candesartan from the many blood pressure-lowering agents available, as it appears to have this additional beneficial effect on regression of retinopathy.”
About 95 percent of diabetics suffer from type 2 diabetes, where cells gradually lose sensitivity to insulin. The illness is often linked to obesity. Around 5 percent of diabetics have the type 1 form, a condition in which the pancreas is unable to produce insulin to regulate blood sugar.Diabetic retinopathy is a potentially blinding illness linked to changes in retinal blood vessels. It is one of the major complications of both type 1 and type 2 diabetes. Intense control of blood sugar levels is the only proven way to reduce incidence and progression of retinopathy, but this kind of control can be elusive. And even when patients do achieve strict control of blood sugars, retinopathy is not always kept at bay.

Previous studies have indicated that drugs known as renin-angiotensin system blockers, which include candesartan, might prevent or reduce the severity of diabetic retinopathy.

This most current research consists of two trials, with three arms total.

In the DIRECT-Prevent 1 study, more than 1,400 type 1 diabetics with existing retinopathy were randomized to receive either Atacand or a placebo; in the DIRECT-Protect 1 trial, more than 1,900 type-1 diabetics with existing retinopathy were randomized to receive either the drug or a placebo.

Individuals receiving Atacand had an 18 percent lower incidence of retinopathy, considered “borderline” statistically significant, the researchers report.

Further analysis of the DIRECT-Protect 1 trial found that progression of retinopathy was 35 percent lower for patients taking Atacand.

Reanalyzing the data in this way somewhat weakens the findings, noted one expert, Dr. Mina Chung, a retinal specialist at the University of Rochester’s Eye Institute. Nevertheless, she added, “this study gives you some evidence that it looks like [Atacand] would be helpful.”

The DIRECT-Protect 2 study randomized more than 1,900 type 2 diabetes patients with mild to moderately severe retinopathy to either Atacand or a placebo.
Again, the difference in progression between the groups was statistically nonsignificant. Improvement increased by 34 percent in the Atacand group versus the placebo group.”Studies have shown that intensive control of blood-sugar levels helps prevent diabetic retinopathy, and now this is another component of the blood pressure effect, but it may also be additional benefits other than just controlling blood pressure,” said Dr. Richard W. Allinson, assistant professor of surgery with the Texas A&M Health Science Center College of Medicine and an ophthalmologist at the Scott & White Waco Clinic.

The trials were funded by AstraZeneca and Takeda. AstraZeneca markets Atacand under license from Takeda.

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Marker for Diabetes Might Miss Early Vision Complication

Tuesday, March 4th, 2008

By Steven Reinberg
HealthDay Reporter
Friday, Feb. 29, 2008; 1:00 PM
Copyright © 2008 ScoutNews, LLC. All rights reserved.

FRIDAY, Feb. 29 (HealthDay News) — Fasting blood sugar levels are typically used to diagnose diabetes, however, a common complication of the disease that can lead to blindness begins at blood sugar levels below what is considered diabetic, Australian researchers report.

Retinopathy is a vascular condition where the small blood vessels in the eye become damaged; other complications of diabetes include heart, kidney and circulatory problems.

“Retinopathy, which is one of the complications traditionally associated with diabetes, occurs at fasting glucose levels below the threshold that is used to define diabetes,” said lead researcher Dr. Tien Y. Wong, chairman of the Department of Ophthalmology at the University of Melbourne.

In the study, Wong’s team analyzed three studies that looked at retinopathy among 11,405 people. The report was published in the March 1 issue of The Lancet.

The researchers found that the overall prevalence of retinopathy ranged from 9.6 percent to 15.8 percent in the general population. In addition, they didn’t find evidence of a particular blood glucose level that would indicate the presence of retinopathy. In fact, 60 percent of retinopathy cases were missed by the current threshold for diabetes diagnosis, which is 7.0 mmol/L.

The finding suggests that eye damage happens much earlier and at lower blood sugar levels than what is currently used to pinpoint the presence of diabetes, Wong said. “This suggests that diagnostic threshold may have to be revised, so that we can pick up more people who are at risk of eye and other complications,” he noted.

In addition to retinopathy, signs of cardiovascular disease also appear to develop at glucose levels below those defined as diabetes, Wong said.

One expert agrees that fasting blood sugar levels may not be the best way of diagnosing diabetes and those at risk for diabetes.

“It is becoming more common that studies are showing that a fasting blood sugar value is not necessarily the best way to judge diabetes or diabetes control,” said Dr. Stuart Weiss, an endocrinologist at New York University Medical Center.

Weiss noted that right now there is no other marker for diabetes. However, many new studies point to the use of blood sugar levels after eating as being better markers for risk, he said.

“Fasting blood sugar is not all that helpful,” Weiss said. “The problem is that a lot of our thinking is based on fasting. That’s an issue we need to focus in on,” he said.

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Eye Complications

Wednesday, November 7th, 2007

You may have heard that diabetes causes eye problems and may lead to blindness. People with diabetes do have a higher risk of blindness than people without diabetes.

But most people who have diabetes have nothing more than minor eye disorders. You can keep minor problems minor. And if you do develop a major problem, there are treatments that often work well if you begin them right away.

Eyesight Insight

To understand what happens in eye disorders, it helps to understand how the eye works. The eye is a ball covered with a tough outer membrane. The covering in front is clear and curved. This curved area is the cornea, which focuses light while protecting the eye.

After light passes through the cornea, it travels through a space called the anterior chamber (which is filled with a protective fluid called the aqueous humor), through the pupil (which is a hole in the iris, the colored part of the eye), and then through a lens that performs more focusing. Finally, light passes through another fluid-filled chamber in the center of the eye (the vitreous) and strikes the back of the eye, the retina.

Like the film in a camera, the retina records the images focused on it. But unlike film, the retina also converts those images into electrical signals, which the brain receives and decodes.

One part of the retina is specialized for seeing fine detail. This tiny area of extra-sharp vision is called the macula.

Blood vessels in and behind the retina nourish the macula. The smallest of these blood vessels are the capillaries.

Glaucoma

People with diabetes are 40% more likely to suffer from glaucoma than people without diabetes. The longer someone has had diabetes, the more common glaucoma is. Risk also increases with age.

Glaucoma occurs when pressure builds up in the eye. In most cases, the pressure causes drainage of the aqueous humor to slow down so that it builds up in the anterior chamber. The pressure pinches the blood vessels that carry blood to the retina and optic nerve. Vision is gradually lost because the retina and nerve are damaged.

There are several treatments for glaucoma. Some use drugs to reduce pressure in the eye, while others involve surgery.

Cataracts

Many people without diabetes get cataracts, but people with diabetes are 60% more likely to develop this eye condition. People with diabetes also tend to get cataracts at a younger age and have them progress faster. With cataracts, the eye’s clear lens clouds, blocking light.

To help deal with mild cataracts, you may need to wear sunglasses more often and use glare-control lenses in your glasses. For cataracts that interfere greatly with vision, doctors usually remove the lens of the eye. Sometimes the patient gets a new transplanted lens. In people with diabetes, retinopathy can get worse after removal of the lens, and glaucoma may start to develop.

Retinopathy

Diabetic retinopathy is a general term for all disorders of the retina caused by diabetes. There are two major types of retinopathy: nonproliferative and proliferative.

Nonproliferative retinopathy is the most common form of retinopathy. In nonproliferative retinopathy, capillaries in the back of the eye balloon and form pouches. Nonproliferative retinopathy can move through three stages (mild, moderate, and severe), as more and more blood vessels become blocked. Although retinopathy does not usually cause vision loss at this stage, the capillary walls may lose their ability to control the passage of substances between the blood and the retina. Fluid can leak into the part of the eye where focusing occurs, the macula. When the macula swells with fluid, a condition called macula edema, vision blurs and can be lost entirely. Although nonproliferative retinopathy usually does not require treatment, macular edema must be treated, but fortunately treatment is usually effective at stopping and sometimes reversing vision loss.

In some people, retinopathy progresses after several years to a more serious form called proliferative retinopathy. In this form, the blood vessels are so damaged they close off. In response, new blood vessels start growing in the retina. These new vessels are weak and can leak blood, blocking vision, which is a condition called vitreous hemorrhage. The new blood vessels can also cause scar tissue to grow. After the scar tissue shrinks, it can distort the retina or pull it out of place — this is called retinal detachment.

Your retina can be badly damaged before you notice any change in vision. Most people with nonproliferative retinopathy have no symptoms. Even with proliferative retinopathy, the more dangerous form, people sometimes have no symptoms until it is too late to treat them. For this reason, you should have your eyes examined regularly by an eye care professional.

Several factors influence whether you get retinopathy. These include your blood sugar control, your blood pressure levels, how long you have had diabetes, and your genes.

The longer you’ve had diabetes, the more likely you are to have retinopathy. Almost everyone with type 1 diabetes will eventually have nonproliferative retinopathy. And most people with type 2 diabetes will also get it. But the retinopathy that destroys vision, proliferative retinopathy, is far less common.

People who keep their blood sugar levels closer to normal are less likely to have retinopathy or to have milder forms.

Treating Retinopathy

Huge strides have been made in the treatment of diabetic retinopathy. Treatments such as scatter photocoagulation, focal photocoagulation, and vitrectomy prevent blindness in most people. The sooner retinopathy is diagnosed, the more likely these treatments will be successful. The best results occur when sight is still normal.

In photocoagulation, the eye care professional makes tiny burns on the retina with a special laser. These burns seal the blood vessels and stop them from growing and leaking.

In scatter photocoagulation (also called panretinal photocoagulation), the eye care professional makes hundreds of burns in a polka-dot pattern on two or more occasions. Scatter photocoagulation reduces the risk of blindness from vitreous hemorrhage or detachment of the retina — but it only works before bleeding or detachment has progressed very far. This treatment is also used for some kinds of glaucoma.

Side effects of scatter photocoagulation are usually minor. They include several days of blurred vision after each treatment and possible loss of side (peripheral) vision.

In focal photocoagulation, the eye care professional aims the laser precisely at leaking blood vessels in the macula. This procedure does not cure blurry vision caused by macular edema. But it does keep it from getting worse.

When the retina has already detached or a lot of blood has leaked into the eye, photocoagulation is no longer useful. The next option is vitrectomy, which is surgery to remove scar tissue and cloudy fluid from inside the eye. The earlier the operation occurs, the more likely it is to be successful. When the goal of the operation is to remove blood from the eye, it usually works. Reattaching a retina to the eye is much harder and works in only about half the cases.

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