Meglitinides

Meglitinides are drugs that also stimulate the beta cells to release insulin. Repaglinide (brand name Prandin) and nateglinide (Starlix) are meglitinides. They are taken before each of three meals.

Product Description

Most important information about Prandin

Pharmacokinetics

Possible Side Effects

More information about PRANDIN (Repaglinide):

FDA MedWatch Alerts

Sciele Signs Exclusive Agreement with Novo Nordisk to Market Prandin and PrandiMet

To get more information about Prandin: PRANDIN MEDICATION.

To buy PRANDIN (Repaglinide) click HERE: My Family Drugstore

“This partnership in the U.S. will enable us to increase the oral treatment options for people with Type 2 diabetes to help them gain good glycemic control,” said Martin Soeters, president of Novo Nordisk Inc. “It will also allow Novo Nordisk to concentrate on bringing our complete portfolio of three insulin analogs to health care providers, which provides the most viable opportunity to both help improve patient outcomes and realize our business aspirations, in the name of Changing Diabetes(R).”
Patrick Fourteau, president and CEO of Sciele Pharma, Inc., added, “We are pleased to initiate this partnership with Novo Nordisk, a company that is widely recognized as a global leader in diabetes care. Prandin(R) and potentially PrandiMet(R) (upon FDA approval) fit well within our Diabetes product portfolio and will be an excellent complement to Fortamet(R). Promoted by our Primary Care sales force, Prandin and PrandiMet will strengthen our presence in the diabetes treatment market.”

While specific terms of the agreement were not disclosed, Sciele Pharma may receive revenue based on certain dollar baseline targets being met. The Company expects this agreement to be immediately accretive, and as a result, is increasing its full-year 2008 revenue guidance to $440 million to $455 million, up approximately $10 million over previously announced guidance. The Company also expects full-year 2008 earnings per share to increase to $1.97 to $2.07 per share, up approximately $0.10 from its previously announced guidance. This guidance does not include any unapproved products except the new Sular formulation, or any potential one-time charges related to the new Sular conversion.

Product Description

Most important information about Prandin

Pharmacokinetics

Possible Side Effects

More information about PRANDIN (Repaglinide):

FDA MedWatch Alerts

To buy PRANDIN (Repaglinide) click HERE: My Family Drugstore

Product Description

Most important information about Prandin

Pharmacokinetics

Possible Side Effects

More information about PRANDIN (Repaglinide):

Sciele Signs Exclusive Agreement with Novo Nordisk to Market Prandin and PrandiMet

To buy PRANDIN (Repaglinide) click HERE: My Family Drugstore

Low blood sugar may occur if meals are missed or delayed after taking a dose of repaglinide; if you exercise more than usual; during illness, especially with vomiting or diarrhea; if you take other medications; after drinking alcohol; and in other situations.

Hypoglycemia or Low blood sugar has the following symptoms:

• shaking; .
• headache; .
• cold sweats; .
• pale, cool skin; .
• anxiety; and.
• difficulty concentrating.

Keep sugary hard candy; chocolate; fruit juice; or glucose tablets on hand to treat episodes of low blood sugar.

Increased blood sugar may occur

• if you eat significantly more food than usual;
• if you exercise less than usual;
• if you take other medications;
• if you have a fever or other illness; and in other situations.

Hyperglycemia or High blood sugar has the following symptoms:

• increased thirst,
• increased hunger, and
• increased urination.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Prandin (Repaglinide)?
Before taking repaglinide, tell your doctor if you are taking any of the following medicines:

• aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid, others), diflunisal (Dolobid), choline salicylate-magnesium salicylate (Trilisate, Tricosal, others), or magnesium salicylate (Magan, Mobidin, Doan’s, others);
• a beta-blocker such as atenolol (Tenormin), metoprolol (Lopressor, Toprol XL), propranolol (Inderal), and others;
• a diuretic (water pill) such as hydrochlorothiazide (HCTZ, HydroDiuril) and others;
• a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate);
• a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Advil, Motrin, Nuprin, others), naproxen (Aleve, Anaprox, Naprosyn, others), ketoprofen (Orudis KT, Orudis, Oruvail), and others;
• a phenothiazine such as chlorpromazine (Thorazine), perphenazine (Trilafon), and thioridazine (Mellaril);
• a steroid medication such as prednisone (Deltasone, others), methylprednisolone (Medrol, others), dexamethasone (Decadron, others), and prednisolone (Prelone, others);
• a sulfa-based drug such as sulfamethoxazole (Bactrim, Septra, others);
• a thyroid medication;
• birth control pills or estrogen replacement therapy;
• erythromycin (E-Mycin, Ery-Tab, E.E.S., others);
• ketoconazole (Nizoral) or itraconazole (Sporanox);
• phenobarbital (Luminal) or mephobarbital (Mebaral);
• phenytoin (Dilantin, Phenytek);
• probenecid;
• rifampin (Rifadin, Rimactane); or
• warfarin (Coumadin).

The medicines listed above may interact with repaglinide or affect blood sugar control. You may require a dosage adjustment or special monitoring during treatment.
Do not take any over-the-counter cough, cold, allergy, pain, or weight-loss medications without first talking to your doctor. These medications may contain sugar or alcohol or affect blood sugar levels.
Drugs other than those listed here may also interact with repaglinide or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

What should I avoid while taking Prandin (Repaglinide)?
Follow diet, medication, and exercise routines very closely. Changing any of these routines can affect blood sugar levels.
Avoid alcohol. It lowers blood sugar and may interfere with diabetes treatment.
Tell your doctor and dentist that you are taking this medication before having surgery.
Do not take any over-the-counter cough, cold, allergy, pain, or weight-loss medications without first talking to your doctor. These medications may contain sugar or alcohol or affect blood sugar levels.

Contraindications
Insulin-dependent (type 1) diabetes; diabetic ketoacidosis with or without coma; hypersensitivity to repaglinide or its ingredients.

Warnings
While taking Prandin, you should check your blood sugar regularly. Your doctor will also watch it; and to measure long-term glucose control, he will probably give you a glycosylated hemoglobin (HbA1C) test as well.
Too much Prandin can cause low blood sugar (hypoglycemia), marked by shaking, sweating, and cold-clammy skin. If you develop these symptoms, take some orange juice or suck on a hard candy. The problem is more likely to surface if you are elderly, debilitated, or malnourished, have liver problems, or suffer from poor adrenal or pituitary function.

Precautions
Your doctor will want to check your progress at regular visits , especially during the first few weeks you take this medicine. It is very important to follow carefully any instructions from your health care team about :

• Alcohol-Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team.
• Other medicines-Do not take other medicines during the time you are taking repaglinide unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems.
• Counseling-Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur in patients with diabetes during pregnancy.
• Travel-Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would normally. Make allowances for changing time zones and keep your meal times as close as possible to your usual meal times.

In case of emergency -There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification (ID) bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says that you have diabetes and a list of all of your medicines.
Too much repaglinide can cause low blood sugar (hypoglycemia). Low blood sugar also can occur if you use repaglinide with another antidiabetic medicine, delay or miss a meal or snack, exercise more than usual, drink alcohol, or cannot eat because of nausea or vomiting. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out) . Different people may feel different symptoms of low blood sugar. It is important that you learn which symptoms of low blood sugar you usually have so that you can treat it quickly .

Symptoms of low blood sugar include anxiety; behavior change similar to being drunk; blurred vision; cold sweats; confusion; cool, pale skin; difficulty in thinking; drowsiness; excessive hunger; fast heartbeat; headache (continuing); nausea; nervousness; nightmares; restless sleep; shakiness; slurred speech; or unusual tiredness or weakness.
If symptoms of low blood sugar occur, eat glucose tablets or gel, corn syrup, honey, or sugar cubes; or drink fruit juice, nondiet soft drink, or sugar dissolved in water to relieve the symptoms. Also, check your blood for low blood sugar. Get to a doctor or a hospital right away if the symptoms do not improve. Someone should call for emergency help immediately if severe symptoms such as convulsions (seizures) or unconsciousness occur . Food or drink should not be forced because the patient could choke from not swallowing correctly.

Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your antidiabetic medicine, overeat or do not follow your meal plan, have a fever or infection, or do not exercise as much as usual.

Symptoms of high blood sugar include blurred vision; drowsiness; dry mouth; flushed, dry skin; fruit-like breath odor; increased urination; ketones in urine; loss of appetite; stomachache, nausea, or vomiting; tiredness; troubled breathing (rapid and deep); unconsciousness; or unusual thirst.
If symptoms of high blood sugar occur, check your blood sugar level and then call your doctor for instructions .

Information For Patients

Pregnancy
Category C.
Repaglinide has not been studied in pregnant women. However, it is easier during pregnancy to control your blood sugar by using injections of insulin, rather than by taking repaglinide. Close control of your blood sugar can reduce the chance of your baby gaining too much weight, having birth defects, or having high blood sugar before birth. Be sure to tell your doctor if you plan to become pregnant or if you think you are pregnant.

Nursing Mothers
It is not known whether repaglinide passes into human breast milk. However, it has been shown to cause unwanted effects in nursing animals. It may be necessary for you to take another medicine or to stop breast-feeding during treatment. Be sure you have discussed the risks and benefits of the medicine with your doctor.

Pediatric Use
Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of repaglinide in children with use in other age groups.

Geriatric Use
This medicine has been tested in a limited number of patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults. However, the first signs of low blood sugar are not easily seen or do not occur at all in older patients. This may increase the chance of low blood sugar developing during treatment.

Product Description

Most important information about Prandin

Pharmacokinetics

More information about PRANDIN (Repaglinide):

FDA MedWatch Alerts

Sciele Signs Exclusive Agreement with Novo Nordisk to Market Prandin and PrandiMet

To buy PRANDIN (Repaglinide) click HERE: My Family Drugstore

• hunger,
• headache,
• drowsiness,
• weakness,
• dizziness,
• fast heartbeat,
• sweating,
• tremor,
• and nausea.

Carry a piece of sugary hard candy or glucose tablets with you to treat episodes of low blood sugar.
Follow diet, medication, and exercise routines very closely. Changing any of these routines can affect blood sugar levels.
Avoid alcohol. It lowers blood sugar and may interfere with diabetes treatment.

What should I discuss with my doctor before taking Prandin (Repaglinide)?
Before taking repaglinide, tell your doctor if you

• have kidney disease;
• have liver disease;
• have Type 1 diabetes mellitus (insulin-dependent diabetes);
• have diabetic ketoacidosis;
• have a serious infection, illness, or injury; or
• need surgery.

You may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
Repaglinide is in the FDA pregnancy category C. This means that it is not known whether repaglinide will be harmful to an unborn baby. Do not take repaglinide without first talking to your doctor if you are pregnant or could become pregnant during treatment.
It is not known whether repaglinide passes into breast milk. Do not take repaglinide without first talking to your doctor if you are breast-feeding a baby.

Product Description

Pharmacokinetics

Possible Side Effects

More information about PRANDIN (Repaglinide):

FDA MedWatch Alerts

Sciele Signs Exclusive Agreement with Novo Nordisk to Market Prandin and PrandiMet

To buy PRANDIN (Repaglinide) click HERE: My Family Drugstore