Posts Tagged ‘Type 1 diabetes’

Eye Complications

Wednesday, November 7th, 2007

You may have heard that diabetes causes eye problems and may lead to blindness. People with diabetes do have a higher risk of blindness than people without diabetes.

But most people who have diabetes have nothing more than minor eye disorders. You can keep minor problems minor. And if you do develop a major problem, there are treatments that often work well if you begin them right away.

Eyesight Insight

To understand what happens in eye disorders, it helps to understand how the eye works. The eye is a ball covered with a tough outer membrane. The covering in front is clear and curved. This curved area is the cornea, which focuses light while protecting the eye.

After light passes through the cornea, it travels through a space called the anterior chamber (which is filled with a protective fluid called the aqueous humor), through the pupil (which is a hole in the iris, the colored part of the eye), and then through a lens that performs more focusing. Finally, light passes through another fluid-filled chamber in the center of the eye (the vitreous) and strikes the back of the eye, the retina.

Like the film in a camera, the retina records the images focused on it. But unlike film, the retina also converts those images into electrical signals, which the brain receives and decodes.

One part of the retina is specialized for seeing fine detail. This tiny area of extra-sharp vision is called the macula.

Blood vessels in and behind the retina nourish the macula. The smallest of these blood vessels are the capillaries.

Glaucoma

People with diabetes are 40% more likely to suffer from glaucoma than people without diabetes. The longer someone has had diabetes, the more common glaucoma is. Risk also increases with age.

Glaucoma occurs when pressure builds up in the eye. In most cases, the pressure causes drainage of the aqueous humor to slow down so that it builds up in the anterior chamber. The pressure pinches the blood vessels that carry blood to the retina and optic nerve. Vision is gradually lost because the retina and nerve are damaged.

There are several treatments for glaucoma. Some use drugs to reduce pressure in the eye, while others involve surgery.

Cataracts

Many people without diabetes get cataracts, but people with diabetes are 60% more likely to develop this eye condition. People with diabetes also tend to get cataracts at a younger age and have them progress faster. With cataracts, the eye’s clear lens clouds, blocking light.

To help deal with mild cataracts, you may need to wear sunglasses more often and use glare-control lenses in your glasses. For cataracts that interfere greatly with vision, doctors usually remove the lens of the eye. Sometimes the patient gets a new transplanted lens. In people with diabetes, retinopathy can get worse after removal of the lens, and glaucoma may start to develop.

Retinopathy

Diabetic retinopathy is a general term for all disorders of the retina caused by diabetes. There are two major types of retinopathy: nonproliferative and proliferative.

Nonproliferative retinopathy is the most common form of retinopathy. In nonproliferative retinopathy, capillaries in the back of the eye balloon and form pouches. Nonproliferative retinopathy can move through three stages (mild, moderate, and severe), as more and more blood vessels become blocked. Although retinopathy does not usually cause vision loss at this stage, the capillary walls may lose their ability to control the passage of substances between the blood and the retina. Fluid can leak into the part of the eye where focusing occurs, the macula. When the macula swells with fluid, a condition called macula edema, vision blurs and can be lost entirely. Although nonproliferative retinopathy usually does not require treatment, macular edema must be treated, but fortunately treatment is usually effective at stopping and sometimes reversing vision loss.

In some people, retinopathy progresses after several years to a more serious form called proliferative retinopathy. In this form, the blood vessels are so damaged they close off. In response, new blood vessels start growing in the retina. These new vessels are weak and can leak blood, blocking vision, which is a condition called vitreous hemorrhage. The new blood vessels can also cause scar tissue to grow. After the scar tissue shrinks, it can distort the retina or pull it out of place — this is called retinal detachment.

Your retina can be badly damaged before you notice any change in vision. Most people with nonproliferative retinopathy have no symptoms. Even with proliferative retinopathy, the more dangerous form, people sometimes have no symptoms until it is too late to treat them. For this reason, you should have your eyes examined regularly by an eye care professional.

Several factors influence whether you get retinopathy. These include your blood sugar control, your blood pressure levels, how long you have had diabetes, and your genes.

The longer you’ve had diabetes, the more likely you are to have retinopathy. Almost everyone with type 1 diabetes will eventually have nonproliferative retinopathy. And most people with type 2 diabetes will also get it. But the retinopathy that destroys vision, proliferative retinopathy, is far less common.

People who keep their blood sugar levels closer to normal are less likely to have retinopathy or to have milder forms.

Treating Retinopathy

Huge strides have been made in the treatment of diabetic retinopathy. Treatments such as scatter photocoagulation, focal photocoagulation, and vitrectomy prevent blindness in most people. The sooner retinopathy is diagnosed, the more likely these treatments will be successful. The best results occur when sight is still normal.

In photocoagulation, the eye care professional makes tiny burns on the retina with a special laser. These burns seal the blood vessels and stop them from growing and leaking.

In scatter photocoagulation (also called panretinal photocoagulation), the eye care professional makes hundreds of burns in a polka-dot pattern on two or more occasions. Scatter photocoagulation reduces the risk of blindness from vitreous hemorrhage or detachment of the retina — but it only works before bleeding or detachment has progressed very far. This treatment is also used for some kinds of glaucoma.

Side effects of scatter photocoagulation are usually minor. They include several days of blurred vision after each treatment and possible loss of side (peripheral) vision.

In focal photocoagulation, the eye care professional aims the laser precisely at leaking blood vessels in the macula. This procedure does not cure blurry vision caused by macular edema. But it does keep it from getting worse.

When the retina has already detached or a lot of blood has leaked into the eye, photocoagulation is no longer useful. The next option is vitrectomy, which is surgery to remove scar tissue and cloudy fluid from inside the eye. The earlier the operation occurs, the more likely it is to be successful. When the goal of the operation is to remove blood from the eye, it usually works. Reattaching a retina to the eye is much harder and works in only about half the cases.

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Type 1 Diabetes Complications

Monday, November 5th, 2007

Heart Disease
People with diabetes have extra reason to be mindful of heart and blood vessel disease. Diabetes carries an increased risk for heart attack, stroke, and complications related to poor circulation.

Kidney Disease (Nephropathy)/Kidney Transplantation
Diabetes can damage the kidneys, which not only can cause them to fail, but can also make them lose their ability to filter out waste products. This is called nephropathy.

Eye Complications
Diabetes can cause eye problems and may lead to blindness. People with diabetes do have a higher risk of blindness than people without diabetes. Early detection and treatment of eye problems can save your sight.

Diabetic Neuropathy and Nerve Damage
One of the most common complications of diabetes is diabetic neuropathy. Neuropathy means damage to the nerves that run throughout the body, connecting the spinal cord to muscles, skin, blood vessels, and other organs.

Foot Complications
People with diabetes can develop many different foot problems. Foot problems most often happen when there is nerve damage in the feet or when blood flow is poor. Learn how to protect your feet by following some basic guidelines.

Skin Complications
As many as one-third of people with diabetes will have a skin disorder caused or affected by diabetes at some time in their lives. In fact, such problems are sometimes the first sign that a person has diabetes. Luckily, most skin conditions can be prevented or easily treated if caught early.

Gastroparesis and Diabetes
Gastroparesis is a disorder that affects people with both type 1 and type 2 diabetes.

Depression
Feeling down once in a while is normal. But some people feel a sadness that just won’t go away. Life seems hopeless. Feeling this way most of the day for two weeks or more is a sign of serious depression.

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Medical Tests and Procedures for Finding and Treating Heart and Blood Vessel Disease

Sunday, November 4th, 2007

What does diabetes have to do with heart disease and blood vessel disease?

If you have diabetes, you’re much more likely to have

· heart disease, also called coronary artery disease

· blood vessel disease, such as atherosclerosis (hardening of the arteries) or peripheral arterial disease (PAD)

· a heart attack

· a stroke

You can cut your chances of having these problems by taking special care of your heart and blood vessels. In addition to regular checkups, your health care team can do special tests to check the condition of your heart and blood vessels. If you already have heart or blood vessel problems, your health care team can use special procedures to open up or bypass narrowed or blocked blood vessels. Choosing foods wisely, being physically active, and taking medications can also help you stay healthy.

Below are some of the medical tests and procedures used for finding and treating heart and blood vessel disease. Terms are listed in alphabetical order.

Angiogram or arteriogram

In an angiogram or arteriogram, dye is injected into the blood vessels using a catheter (small tube) and X rays are taken. This test shows whether arteries are narrowed or blocked. A coronary angiogram checks for narrowing or blockages in the blood vessels that go to the heart. A cerebral arteriogram checks the blood vessels that go to the brain.

Angioplasty

Angioplasty, also called balloon angioplasty, is a procedure used to remove a blockage in a blood vessel to the heart (coronary angioplasty) or the brain. A small tube with a balloon attached is threaded into the narrowed or blocked blood vessel. Then the balloon is inflated, opening the narrowed artery. A wire tube, called a stent, may be left in place to help keep the artery open.

Ankle brachial index

A test called an ankle brachial index (ABI) is used to diagnose PAD. The health care provider compares the blood pressure in the ankle to that in the arm. Lower blood pressure in the lower part of the leg compared to the pressure in the arm may indicate PAD.

Coronary artery bypass graft

During a coronary artery bypass graft, also called a bypass or CABG (pronounced “cabbage”), a blood vessel taken from the leg, wrist, or chest is attached to the coronary artery to bypass a blockage and restore blood flow to the heart. A bypass graft can also be used for blood vessels leading to the brain.

Carotid artery surgery

Carotid artery surgery, also called carotid endarterectomy, is used to remove buildups of fat inside the artery and to restore blood flow to the brain.

CT scan

A CT (computed tomography), also called a CAT scan, uses special scanning techniques to provide images.

Cardiac catheterization

Cardiac catheterization is used in conjunction with other tests. A small tube is inserted into an artery and guided into a blood vessel.

Chest X-ray

This test shows the size and shape of the heart and can also show congestion in the lungs.

Echocardiogram

An echocardiogram uses very-high-frequency sound waves (ultrasound) to produce images of the heart and blood vessels on a screen. Results indicate whether the heart is pumping blood correctly. A stress echocardiogram uses either exercise or medication and ultrasound to provide images of the heart and blood vessels.

Electrocardiogram

An electrocardiogram, also called an ECG or EKG, provides information on heart rate and rhythm and shows whether there has been damage or injury to the heart muscle.

Exercise perfusion test

An exercise perfusion test, also called a stress nuclear perfusion test, uses small amounts of radioactive material to produce images of blood flow to the heart as you exercise.

Exercise stress test

Exercise stress tests are used to find heart disease that is evident only during physical activity. These tests can also be used to help a patient choose the most appropriate physical activity program. Also called a treadmill test, a stress test uses an ECG to measure how the heart performs during activity, such as walking on a moving treadmill. A medication stress test uses medication instead of exercise to increase the heart rate.

Holter monitoring

A holter monitor is a small, portable machine that records the heart’s electrical activity. The person wearing the monitor keeps track of symptoms and activities for the evaluation period. Readings on the machine are compared to the symptoms.

MRI

MRI (magnetic resonance imaging) uses special scanning techniques to provide images of body tissues. MRA (magnetic resonance angiography) uses MRI to examine blood vessels.

Nuclear ventriculography

Nuclear ventriculography, also called radionuclide ventriculography, uses small amounts of radioactive material to check heart function either while the body is at rest or during exercise. This test can also be used to check the blood vessels that go to the brain.

PET scan

A PET (positron emission tomography) scan uses special scanning techniques to provide images of body tissues.

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Islet transplantation

Tuesday, October 23rd, 2007

If scientists can develop safe immunosuppressants that always work, then many people with type 1 diabetes may choose to have pancreas transplants. Until then, many doctors think islet transplants are a better option. Islets are clusters of cells in the pancreas that make insulin. In people with type 1 diabetes, islet cells are destroyed. Only 1-2% of the pancreas is made up of islet cells.

In pancreatic islet transplantation, cells are taken from a donor pancreas and transferred into another person. Once implanted, the new islets begin to make and release insulin. Researchers hope that islet transplantation will help people with type 1 diabetes live without daily injections of insulin.

The Edmonton Protocol

In the 1970s, islet transplant experiments were conducted with great success in laboratory mice. The excitement that those experiments generated soon turned to frustration, as initial attempts to reproduce that success in humans were largely disappointing. For many years progress was slow, and few transplant recipients were able to stay diabetes-free for more than a few months before the transplanted islet cells failed. But in recent years, scientists have begun to make rapid advances in transplant technology, and some of the most exciting new research comes to us from researchers at the University of Alberta in Edmonton, Canada. These scientists have used a new procedure called the Edmonton Protocol to treat patients with type 1 diabetes.

In this procedure, researchers use specialized enzymes to remove islets from the pancreas of a deceased donor. For an average-size person (70 kg), a typical transplant requires about 1 million islets, equal to two donor organs. Because the islets are extremely fragile, transplantation occurs immediately after they are removed.

The transplant itself is easy and takes less than an hour to complete. The surgeon uses ultrasound to guide placement of a small plastic tube (catheter) through the upper abdomen and into the liver. The islets are then injected through the catheter into the liver. The patient will receive a local anesthetic. If a patient cannot tolerate local anesthesia, the surgeon may use general anesthesia and do the transplant through a small incision.

It takes some time for the cells to attach to new blood vessels and begin releasing insulin. The doctor will order many tests to check blood glucose levels after the transplant, and insulin may be needed until control is achieved.

Benefits and Risks

Immunosuppressive or anti-rejection drugs are needed to keep the transplanted islets functioning. Researchers do not fully know what long-term effects these drugs may have. Also, although the early results of the Edmonton Protocol are very encouraging, more research is needed to answer questions about how long the islets will survive and how often the transplantation procedure will be successful.

However, transplanting islet cells has several advantages over transplanting a pancreas. First, unlike the pancreas transplant, an islet transplant is a minor surgical procedure, is less expensive, and is probably safer. Second, scientists may learn how to protect these cells from attack by the immune system. Several methods are already under study. If successful, the person with an islet transplant would not need to take immunosuppressants. Surgery would then be safer and more effective for many people with type 1 diabetes.

There is also continuing research on the transplantation of animal islets. Because the supply of human islets is severely limited, even the most successful method of human islet transplantation could only cure a small fraction of the people with diabetes through existing sources of human islets from donor pancreases. If islets from animal sources (for example, pigs) could be made to work successfully, a cure would be available for everyone. But transplants between species involve a whole new set of problems when it comes to regulating the body’s immune response, so much work will still have to be done to make that a possibility.

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Type 1 Diabetes Conditions & Treatments

Monday, October 22nd, 2007

In type 1 diabetes, the body does not produce insulin, which is needed to take sugar (glucose) from the blood to the cells. You can learn more about these conditions and how to prevent them in this section. You will also find helpful information about insulin, diagnostic tests and tips on what to expect from your health care provider.

Hypoglycemia
Hypoglycemia, or low blood glucose, can happen even during those times when you’re doing all you can to manage your diabetes.

Hyperglycemia
Hyperglycemia is a major cause of many of the complications that happen to people who have diabetes. For this reason, it’s important to know what hyperglycemia is, what its symptoms are, and how to treat it.

Ketoacidosis
Ketoacidosis is a serious condition where the body has dangerously high levels of ketones — or acids that build up in the blood — and it can lead to diabetic coma (passing out for a long time) or even death.

Managing Your Blood Glucose

Keeping your blood sugar (glucose) as close to normal as possible helps you feel better and reduces the risk of long-term complications of diabetes.

- Checking Your Blood Glucose
People with diabetes work to keep their blood glucose as near to normal as possible. Keeping your blood glucose in your target range can help prevent or delay the start of diabetes complications such as nerve, eye, kidney, and blood vessel damage.

- Tight Diabetes Control
Keeping your blood glucose levels as close to normal as possible can be a lifesaver. Tight control means getting as close to a normal (nondiabetic) blood glucose level as you safely can.

- A1C Test
An A1C test gives you a picture of your average blood glucose control for the past 2 to 3 months. The results give you a good idea of how well your diabetes treatment plan is working.

About Insulin and other drugs
In people with type 1 diabetes, the pancreas no longer makes insulin. The beta cells have been destroyed. They need insulin shots to use glucose from meals. Learn more about insulin and other drugs.

Insulin Therapy

Insulin Storage

Insulin Pumps
Learn how you can use an insulin pump to help manage your diabetes.

Transplantation
Diabetes sometimes damages kidneys so badly that they no longer work. When kidneys fail, one option is a kidney transplant. There are also pancreas transplants, as well as islet cell transplants.

- Kidney transplantation

- Pancreas transplantation

- Islet transplantation

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